My friend and I got into an argument about which one of our favorite super heroes, Spider-man and Hulk respectively, would win in a 1 on 1. I said there is no way that Spider-Man would win and she claimed that he would just use "poison web balls" and poison the Hulk. Is that even possible? Can the Hulk be affected by poisons?
If I remember correctly, there's an episode of the Hulk cartoon where the Hulk does, indeed, get poisoned. I odn't know if that's canon, though, even though it's an official cartoon. The plot of that episode involved the Hulk being poisoned, and his friends having to make him angry for him to burn the poison out of his system.
I don't know of any instances in the comic canon where the Hulk has been poisoned. However, judging from the cartoon, I'd say that it's possible - however, the Hulk would likely metabolize the poison from his system fairly quickly (quicker if he's angry and doing a lot of activity).
Edit: Err....I guess I misremembered the episode, but I found it here. (http://www.imdb.com/title/tt0610944/) The Hulk is actually hit with a tranquilizer - he has to burn it out of his system. As such, the Hulk may be susceptible to drugs, but he'd still be able to overcome it - additionally, there's the issue of getting it into his system in the first place (as in the episode, I think they used a "tranquilizer ray" or something weird.