This should be easy for someone to remember but I'm having no luck searching for it on the internet.
The UK comic 2000AD featured, very early on, a long running series about a giant shark and the people trying to hunt it. It ended on a very gruesome note
with the main character being eaten by the shark
What was the name of that story series?
I've been through my 2000 AD collection up to issue 100, and I can't find any story matching your description. Are you sure you're not getting mixed up with a story about a great white shark called Hook Jaw that was published in a comic called Action. If you Google this you'll find comments that it inspired the 2000 AD story about a polar bear called Shako.
Sadly I have never owned any copies of Action so I can't check whether the Hook Jaw story matches your description. This site reports it ends with a main character, Red McNally, being eaten by the shark.
Could you be thinking of Flesh - a 2000AD comic about people going back in time to hunt dinosaurs for meat? I recall that involving some prehistoric sharks or shark/crodilian dinosaurs.
