Is Wedge Antilles (of Rogue Squadron) related to Captain Antilles (of Leia Organa's Tantive IV from Episode 4) in-universe? (G to C canon).
I couldn't find any mention of relation (or its absense) in Wedge's Wookieepedia page.
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They aren't related. Antilles is simply a common surname, like Smith.
Two Bails, two different characters. It should be noted that "Antilles" is sort of the Star Wars equivalent of "Jones," and "Smith." There have been numerous characters throughout the films, books, and expanded universe material named Antilles, but almost none of them are directly related. For instance, Corellian hotshot starfighter pilot Wedge Antilles is not related to Bail Antilles. Nor is he related to C-3PO and R2-D2's former master, Captain Antilles, the Rebel officer whom Vader chokes to death in the opening moments of A New Hope.
This is also referenced in information about Wedge:
Wedge Antilles is from Corellia. For more information on Wedge, please visit the alt.fan.wedge news group. On the Official Site Steve Sansweet explains "it should be noted that 'Antilles' is sort of the Star Wars equivalent of 'Jones', and 'Smith'. There have been numerous characters throughout the films, books and expanded universe material named Antilles, but almost none of them are directly related."
A Human male Corellian, Wedge Antilles was born in 21 BBY, the son of Jagged Antilles and his wife Zena, who owned a fueling depot in the Gus Treta Inner-System Market Station over the planet Corellia.
Given that he was from Corellia, and a businessman, it seems unlikely that he knew closely the pilot of the Tantative IV. But we can answer better!
Raymus Antilles was a male Human and the captain of the Corvette Sundered Heart at the time of the Clone Wars and the Galactic Civil War. He served the Royal Alderaan Civil Fleet under Senator Bail Prestor Organa.
Raymus Antilles was a male Human from the peaceful planet of Alderaan, one of the so-called Core Worlds of the Galactic Republic. He was a member of the prominent House of Antilles and the uncle of Corla Metonae
According to behind the scenes,
The Antilles name originated with a separate character named Bail Antilles in early drafts, before it became the Chewie character's surname.
George Lucas proposed that Denis Lawson, the actor that played Wedge Antilles in the original trilogy, might make a cameo as Raymus Antilles
However, this doesn't prove anything in-universe. It is difficult, probably impossible, to prove they were not related. However, given that they were from different planets, and one was actually closely related to royalty, it seems highly unlikely that they were closely related. It is possible they shared a distant ancestor, or were related by marriage, but unless new information comes out, we likely can't answer this question.
I wrote this article about Captain Antilles, not to be confused with the Wedge character.