The mutant Colossus in X-men is a tank: he's big, strong, and tough. He can take it and dish it out. He's big, and gets bigger when he activates his mutant ability: he grows at least a foot in height, gains superhuman strength, and his body transforms into a form of 'organic steel'.
In his armored form, he's bulletproof, highly resistant to all physical damage (including heat and cold, explosions, etc), and able to go without food, water, or oxygen for extended periods - maybe indefinitely.
Are his eyes a weak point? I know he can still see, and thus be blinded, but are his eyes more vulnerable to physical damage than the rest of him?