In The French Mistake, Sam does some research into the history of our universe and finds that none of the apocalyptic events that look place in Season 5 in his universe, occurred in ours. However, I'm slightly confused at swine flu. Apparently this was created by Pestilence as part of his plan to spread the croatoan virus through the vaccine. But swine flu also took place in the universe of Jared Padalecki and Jensen Ackles (our universe), so why didn't Sam see anything about swine flu?
Perhaps Pestilence didn't actually created swine flu, or the universe in the French Mistake wasn't precisely ours, since that wasn't Jared Padalecki's house.