I've seen the Adamantium covering over Wolverine's skeleton discussed here before, as well as on many sites on the web. I've also seen different info on what was covered. I'm not a huge X-Men fan, but I do enjoy the characters and stories, so I know I'm probably missing out on a lot, and may have missed the obvious along the way because I didn't read a particular series or something like that.
I had a relative die from leukemia a few years ago and that reminded me of basic junior high science: that red and white blood cells are produced in the bone marrow and must be able to reach from the marrow into the blood vessels. The leukemia my relative had was the kind where the "bad" cells would surround the marrow and prevent the new "good" blood cells from getting out to the rest of the body.
So just how much of Wolverine's skeleton is covered with Adamantium? If it's the whole thing, there'd have to be openings for new red blood cells to get out if he is to remain alive. I've never seen a reference to this issue, is it ever addressed?
That also raises another issue along the same line: Are hard to reach areas, such as ball and socket joints covered? If not, then stress on other covered areas could be transferred to the weaker uncovered areas, which would lead to breakage there. And if joints like that are covered, is there anything to say how it was done?
Are there openings or gaps in the Adamantium covering on his body? Are there any references to any of these issues that deal with them?