The show featured the heads of live action actors pasted onto ridiculously small CGI bodies. There was a bight red moronic alien character, the captain was a drunk, the badass tactical specialist was played by a woman with a fake mustache. Thought it was brilliant and want to watch it again.
As per William's comment above, this would be Outer Space Astronauts.
In the future, many courageous souls journey to the far reaches of the galaxy, seeking knowledge, adventure, and the thrill of exploration. They are integral to the survival of the human race and truly have 'the right stuff.' The rest are the Outer Space Astronauts. The slovenly Captain Ripley commands the "space-ially" challenged crew of the O.S.S. Oklahoma as they go about their daily routine of... working in space.