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Diana is the witch in question. Lion blood she got from Phillippe when he blessed her with his blood vow. The name Diana is the Roman equivalent of the Greek goddess of the hunt (Artemis) and wolves are part of her remit. When Phillippe takes Diana and Matthew to the old ruined temple and asks Artemis for a blessing, Artemis graces her to show her approval. Also as Matthew is now part of Diana, by marriage and also as she shares her blood with him and he in turn share his blood with her. So taking all this into consideration she is the witch with the blood of the wolf. The part of the prophecy saying "she will destroy the children of the night"...in the book its made clear that the vampires have reigned supreme over all other creatures for centuries, and view witches and deamons as inferior. Diana 'destroys' the vampires rule and brings them down to size by decoding the 'book of life' and bringing the truth of all creature DNA to light. Deamons previously viewed as the mad and weakest of creatures are now seen as the basis of all creature life.