As I'm currently reading through the Avengers books from this time frame:

 - Reed's participation with the Illuminati in *NEW AVENGERS* was due to his having a back-door to contact Earth that he didn't tell the rest of the FF about. He was, indeed, on that search for a cure to his condition; however, the impending destruction of the universe was worth a few minor interruptions.

 - In *AGE OF ULTRON*, the FF returned to Earth after Ultron had taken over, and only Sue survived. Once the timeline was reset, of course, none of that needed to happen, so it didn't.

 - One of the reasons Tony pushed for the expansion of the Avengers' roster seen in *AVENGERS* at that time was to help free him up to spend more time dealing with the incursions. In fact, he was one of the few Avengers who did not go into space to fight the Builders in the "Infinity" storyline, precisely so he could stay on Earth to deal with incursions.

 - I've gotten the impression that, possibly, the multiple time travel trips seen in *AGE OF ULTRON* are connected to the collapse of the Marvel multiverse. While it's not the only possible cause (the events happening out in the universe during "War of Kings" and "Realm of Kings" definitely ripped a hole in the universe), the strong warnings and concern about using time travel to fix the problem, followed by the fact that there were multiple trips by the same people to the same time, seems like a strong candidate for causing major problems. This is certainly not explicitly stated anywhere; I simply feel like it was being hinted at.