What's the oldest "accidental (potion) ingredient as inciting incident" story?

Is it 1886's [The Strange Case of Dr. Jekyll and Mr. Hyde](https://tvtropes.org/Literature/TheStrangeCaseOfDrJekyllAndMrHyde), where the accidental ingredient is a "impurity of [unknown] salt", apparently?

The TVTropes entry for this event seems to be a possible variant of what they call [Accidental Discovery](https://tvtropes.org/Main/AccidentalDiscovery), [Freak Lab Accident](https://tvtropes.org/Main/FreakLabAccident), or [Miraculous Malfunction](https://tvtropes.org//Main/MiraculousMalfunction).