As it says in the title:

**Is Skye's mother based on a character from the comics?**

Her father, Cal, has been [confirmed](http://marvel.com/news/tv/23795/debriefing_the_marvels_agents_of_shield_winter_finale#ixzz3LXVAiQIT) to be [Mister Hyde](http://en.wikipedia.org/wiki/Mister_Hyde_%28comics%29), is her mother based on another comic character?

**Related Question:** https://scifi.stackexchange.com/q/74467/20557