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This tag should be used for questions in which the impact of a drug (real or fictional) on the thinking and/or behavior of a major character is critical to the plot.
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Accepted
Novel. Parents drugged kid(s) to lower intelligence due to blackmail/threats. Attempts were ...
I suspect this is "Sporting Chance" (1994) by Elizabeth Moon (author of Vatta's War). The story involves a prince who had been drugged to make him less intelligent to avoid a risk to the king.