The Stark family were responsible for quite a lot of them.
1. Whiplash aka Ivan Vanko
Vanko's father was apparently [kind of] betrayed by Howard Stark that led to his death. Ivan thus made his life's goal to destroy the Starks.
Ivan: What your father did to my family over 40 years, I will do to you in 40 minutes.
Iron-Man 2 (2010)
Also Fury clears ...