19
Data's brain represents a sticking point in the replication process.
It's spelled out explicitly in the EU novel, Immortal Coil. Note that it isn't the complexity of the brain that's the problem, but rather some sort of 'x factor' that stops a replicated brain from going kerflooey like Lal's brain did in TNG: The Offspring.
“...Because he was family,” ...
12
Only Moriarty gained sentience through a glitch, or rather a poorly-thought request to the computer. The Doctor achieved it through time, when his program far exceeded the designed running time and with some coaching from the crew. Vic Fontaine was specifically programmed with knowledge of his status as a hologram, but he doesn't seem any more sentient than ...
8
Being a symbiote's first host is probably best described as a vocation. The individual will spend the remainder of their life in service of the symbiote, it doesn't attract much cachet and there aren't even any particular benefits to the individual.
Elma was a year ahead of Moll, but until they were assigned to the same Quad, she had never seen the Holt ...
7
To your question about intentionally creating a new lifeform/sentient in the holodeck I might suggest the character of Minuet as the closest possibility.
Prior to the program's initiation, the holodeck had been upgraded by the Bynars and it was immediately clear that Minuet was different from any other holodeck character.
In this case the Bynar's ...
2
I'd have to say that it's possible, under the right circumstances.
Second Chances
Episode 24 of season 6 shows that Commander William Riker was accidentally duplicated in an incident described as a transporter accident. While being transported back to his ship, part of the transporter beam was reflected back to the planet, where Riker was re-materialized ...
1
The obvious answer, that avoids all the nonsense of faster than light sensors vs sub light speed sensors, is Damon Bok's son being an inexperienced Damon, interested more in profit and lacking the tactical awareness to react quickly enough to Picard's tactic.
Also given the timeframe of the Picard Maneuver from start to finish would have been mere ...
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