In the episode "threat of eXtinction", we learn that the father, Reed Strucker, is the grandson of Andreas von Strucker. There was no mention of how Andreas and his twin relate to other characters in the Marvel Universe.
However, Hydra and Baron Strucker are intellectual properties of the MCU/Disney while X-men & mutants are Fox properties. That means ...
The evidence is currently ambiguous.
In the scene where the connection is revealed, Otto specifically says,
"This is my father, Andreas von Strucker. My father and his sister Andrea did unspeakable things. They were terrorists. They were also mutants."
This implies that only Andreas is his parent, and Andrea is not.
Now, you could imagine, "He was ...