No spoilers, please!
My friend and I plan to see Deadpool soon, but she hasn't seen any of the X-Men movies. Would she benefit at all from having seen the X-Men movies (or at least, any specific ones) before Deadpool?
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Deadpool makes a few references to events of Days of Future Past, lots of references to the character of Wolverine (and Wolverine: Origins in particular), and comments on the X-Men franchise as a whole. (There are also a few references to the Green Lantern movie).
Some jokes will go over the heads of people who haven't seen those movies, but there are a lot of jokes.