In the Dune series, spice is noted for its geriatric properties - the ability to extend human life well beyond the natural norm. In "God Emperor of Dune", Leto II reflects on that property:
Without the geriatric properties of melange, people live and die according to the ancient measure-no more than a hundred years or so.
However, most of the humans we see in the series are of an age well within that norm. Obvious exceptions would be Leto himself or the Duncan gholas. However, that begs the question of what lifespans actually were in a spice-rich civilization.
How much could spice extend a human life in Dune, and what character is an example of it?
Note that by an example I mean someone who lived beyond the "hundred years or so", yet still maintained youth and/or vitality.