In "The Stars my Destination" some humans permanently transfer their mind into a machine without any external sensation. They hope to achieve a higher level of enlightment through undisturbed meditation. Needless to say all of them go slowly insane.
I read another story once which dealt with the same theme. A scientist uploads the mind of his wife into a cube (some kind of small computer) without Input or Output. I'm pretty sure after an argument the protagonist destroys the cube after pointing out the cruelty of cutting all sensations from a human. I feel that it might have been written by Asimov but don't know for sure.
Does anybody know the name or author of this story?