The in Stargate: Atlantis season 1 episode 7 “Underground” we meet the Genii. Their plan is to build nuclear weapons, place them on all the hibernating Wraith ships, and take them all down at once. They are planning for about 50 more years of preparation to be able to do this. Dr Weir says that there plan would never work "With or without our help." Implying that a coordinated strike at 60+ targets at once was unfeasible.
In less than 50 years, the US alone went from 3 warheads to over 2000, and were capable of delivering multiple warheads at the same time. Even if the strikes were off by a few minutes, or even hours, the nukes being on board the Hive Ships would still be effective. This was shown by Daedalus when their transporters were still effective. The Wraith counter measures made the transporters not work, not the nuclear weapons.
It seems to me that the Genii's plan of a coordinated, or nearly coordinated, strike on the Wraith would indeed be successful, provided they had enough Uranium after 50 years of mining, and were able to accurately decode the Wraith information and find all the Hives. So, why would the plan not work?