In The Incredible Hulk, Mr. Blue became infected with Hulk's blood just after Abomination was created. Also, Mr. Blue's head started to show some kind of mutation. What happened to him?
What troubles me: What was the point of showing the infection and mutation? Has he become something notable that Marvel Cinematic Universe has yet to show? Anything from comics?
The character referred to in the Incredible Hulk film as 'Mr Blue' (e.g. Dr. Samuel Sterns) is referred to elsewhere in the Marvel Comic canon as "The Leader", a super-intelligent megalomaniac with an
'oversized brain housed in a towering cranium, often portrayed as the Hulk's nemesis'
Focusing on the film canon, a recent interview with 'Incredible Hulk' Producer Gale Anne Hurd has indicated that the decision to include a scene in which Professor Stern's forehead is infected with Banner's blood was a deliberate decision to pay homage to the Marvel villain (to which she owns the rights). She goes on to say that she is hopeful that the original character actor, Tim Blake Nelson will return to play The Leader in the upcoming Hulk 2 sequel;
“The Leader,” she said when asked what Nelson was transforming into when last we saw him. “It would be a blast [to put The Leader in the sequel], and Tim Blake Nelson is tremendous and a very talented filmmaker in his own right.”
“When I think of all the many, many, many villains in the Hulk universe, we’ve now done the Abomination, so wouldn’t it be great to tackle the Leader?” she beamed. “It’s a completely different type of cerebral villain, which would give the movie a terrific new take on the character.”
