I came a across a Reddit comment that asked whether or not Superman is ticklish. One commenter replied with this image, but that doesn't really answer the question.
Although it sounded like a stupid question at first, tickling someone could certainly be used to bring their guard down and make them easier to incapacitate.
I am not at all familiar with Superman lore, but is there anything to suggest that he is immune to tickle attacks or is he ticklish like normal people would be?