In the Guardians of the Galaxy movie it is stressed that a mortal human cannot wield the Infinity Stones. In the comics, however, several humans appear to have wielded one or more Infinity Gems including The Hood, Iron Man, Dr. Strange, Mr. Fantastic, Beast, and Charles Xavier. I don't know the details of most of these, however, as I learned of some of them via Wikipedia...
In Thor: The Dark World I can only imagine that Natalie Portman’s character somewhat wielded the red gem, though she definitely did not appear to be in control of it.
I would suggest that the human-destroying nature of the purple stone in Guardians could be exclusive to that one stone, but Power and Reality (the gems that seem to fit the appearance of the purple stone) were both wielded in the comics by The Hood.
So my question/s: is the idea that a simple human cannot wield the gem exclusive to the MCU/Earth 199999? Do human characters in Earth 616 (or others) have some way to more safely wield them?